Ontology highlight
ABSTRACT:
SUBMITTER: Apgar JF
PROVIDER: S-EPMC3505121 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Apgar Joshua F JF Witmer David K DK White Forest M FM Tidor Bruce B
Molecular bioSystems 20100617 10
Computational models are increasingly used to understand and predict complex biological phenomena. These models contain many unknown parameters, at least some of which are difficult to measure directly, and instead are estimated by fitting to time-course data. Previous work has suggested that even with precise data sets, many parameters are unknowable by trajectory measurements. We examined this question in the context of a pathway model of epidermal growth factor (EGF) and neuronal growth facto ...[more]