Ontology highlight
ABSTRACT:
SUBMITTER: Christie JM
PROVIDER: S-EPMC3505452 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Christie John M JM Arvai Andrew S AS Baxter Katherine J KJ Heilmann Monika M Pratt Ashley J AJ O'Hara Andrew A Kelly Sharon M SM Hothorn Michael M Smith Brian O BO Hitomi Kenichi K Jenkins Gareth I GI Getzoff Elizabeth D ED
Science (New York, N.Y.) 20120209 6075
The recently identified plant photoreceptor UVR8 (UV RESISTANCE LOCUS 8) triggers regulatory changes in gene expression in response to ultraviolet-B (UV-B) light through an unknown mechanism. Here, crystallographic and solution structures of the UVR8 homodimer, together with mutagenesis and far-UV circular dichroism spectroscopy, reveal its mechanisms for UV-B perception and signal transduction. β-propeller subunits form a remarkable, tryptophan-dominated, dimer interface stitched together by a ...[more]