Ontology highlight
ABSTRACT:
SUBMITTER: Wei C
PROVIDER: S-EPMC3505761 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Wei Chaoliang C Wang Xianhua X Chen Min M Ouyang Kunfu K Song Long-Sheng LS Cheng Heping H
Nature 20081231 7231
Directional movement is a property common to all cell types during development and is critical to tissue remodelling and regeneration after damage. In migrating cells, calcium has a multifunctional role in directional sensing, cytoskeleton redistribution, traction force generation, and relocation of focal adhesions. Here we visualize high-calcium microdomains ('calcium flickers') and their patterned activation in migrating human embryonic lung fibroblasts. Calcium flicker activity is dually coup ...[more]