Ontology highlight
ABSTRACT:
SUBMITTER: Liu G
PROVIDER: S-EPMC3506201 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Liu Guangxian G Yang Wuwei W Guo Mei M Liu Xiaoqing X Huang Naixiang N Li Dingfeng D Jiang Zefei Z Yang Wenfeng W Zhang Weijing W Su Hang H Liu Zhiqing Z Liu Tieqiang T Wang Dongmei D Huang Shan S Yao Bo B Man Qiuhong Q Qiu Lijuan L Sun Xuedong X Sun Yuying Y Liu Bing B
Cancer immunology, immunotherapy : CII 20120622 12
Overinduced CD4(+)CD25(+high) regulatory T cells (Treg) and downregulated NK cells contribute to tumor-relevant immune tolerance and interfere with tumor immunity. In this study, we aimed to design a novel strategy with cytokine combination to correct the dysregulated Treg and NK cells in malignant patients. Initially, a total of 58 healthy individuals and 561 malignant patients were analyzed for their cellular immunity by flow cytometry. The average percentages of CD4(+)CD25(+high)/lymphocyte w ...[more]