Ontology highlight
ABSTRACT:
SUBMITTER: Yuan Z
PROVIDER: S-EPMC3506484 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Yuan Zhongshang Z Gao Qingsong Q He Yungang Y Zhang Xiaoshuai X Li Fangyu F Zhao Jinghua J Xue Fuzhong F
BMC genetics 20121008
<h4>Background</h4>Currently, most methods for detecting gene-gene interaction (GGI) in genomewide association studies (GWASs) are limited in their use of single nucleotide polymorphism (SNP) as the unit of association. One way to address this drawback is to consider higher level units such as genes or regions in the analysis. Earlier we proposed a statistic based on canonical correlations (CCU) as a gene-based method for detecting gene-gene co-association. However, it can only capture linear re ...[more]