Ontology highlight
ABSTRACT:
SUBMITTER: Almendros C
PROVIDER: S-EPMC3506596 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Almendros Cristóbal C Guzmán Noemí M NM Díez-Villaseñor César C García-Martínez Jesús J Mojica Francisco J M FJ
PloS one 20121126 11
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR associated (cas) genes conform the CRISPR-Cas systems of various bacteria and archaea and produce degradation of invading nucleic acids containing sequences (protospacers) that are complementary to repeat intervening spacers. It has been demonstrated that the base sequence identity of a protospacer with the cognate spacer and the presence of a protospacer adjacent motif (PAM) influence CRISPR-mediated interference effi ...[more]