Ontology highlight
ABSTRACT:
SUBMITTER: Matsunaga Y
PROVIDER: S-EPMC3506605 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Matsunaga Yasuhiro Y Koike Ryotaro R Ota Motonori M Tame Jeremy R H JR Kidera Akinori A
PloS one 20121126 11
Structural symmetry in homooligomeric proteins has intrigued many researchers over the past several decades. However, the implication of protein symmetry is still not well understood. In this study, we performed molecular dynamics (MD) simulations of two forms of trp RNA binding attenuation protein (TRAP), the wild-type 11-mer and an engineered 12-mer, having two different levels of circular symmetry. The results of the simulations showed that the inter-subunit fluctuations in the 11-mer TRAP we ...[more]