RELATCH: relative optimality in metabolic networks explains robust metabolic and regulatory responses to perturbations.
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ABSTRACT:
SUBMITTER: Kim J
PROVIDER: S-EPMC3506949 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Publications
RELATCH: relative optimality in metabolic networks explains robust metabolic and regulatory responses to perturbations.
Kim Joonhoon J Reed Jennifer L JL
Genome biology 20120705 9
Predicting cellular responses to perturbations is an important task in systems biology. We report a new approach, RELATCH, which uses flux and gene expression data from a reference state to predict metabolic responses in a genetically or environmentally perturbed state. Using the concept of relative optimality, which considers relative flux changes from a reference state, we hypothesize a relative metabolic flux pattern is maintained from one state to another, and that cells adapt to perturbatio ...[more]
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