Ontology highlight
ABSTRACT:
SUBMITTER: Morgan XC
PROVIDER: S-EPMC3506950 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Morgan Xochitl C XC Tickle Timothy L TL Sokol Harry H Gevers Dirk D Devaney Kathryn L KL Ward Doyle V DV Reyes Joshua A JA Shah Samir A SA LeLeiko Neal N Snapper Scott B SB Bousvaros Athos A Korzenik Joshua J Sands Bruce E BE Xavier Ramnik J RJ Huttenhower Curtis C
Genome biology 20120416 9
<h4>Background</h4>The inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis result from alterations in intestinal microbes and the immune system. However, the precise dysfunctions of microbial metabolism in the gastrointestinal microbiome during IBD remain unclear. We analyzed the microbiota of intestinal biopsies and stool samples from 231 IBD and healthy subjects by 16S gene pyrosequencing and followed up a subset using shotgun metagenomics. Gene and pathway composition wer ...[more]