Ontology highlight
ABSTRACT:
SUBMITTER: Benson DM
PROVIDER: S-EPMC3507143 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Benson Don M DM Hofmeister Craig C CC Padmanabhan Swaminathan S Suvannasankha Attaya A Jagannath Sundar S Abonour Rafat R Bakan Courtney C Andre Pascale P Efebera Yvonne Y Tiollier Jérôme J Caligiuri Michael A MA Farag Sherif S SS
Blood 20121001 22
Natural killer (NK) cells elicit cytotoxicity against multiple myeloma (MM); however, MM cells express HLA class I molecules as ligands to NK cell inhibitory killer immunoglobulin-like receptors (KIRs) as a means of immunoevasion. KIR-ligand mismatch may improve outcomes in allogeneic transplantation for MM. Extrapolating on this concept, we conducted a phase 1 trial of IPH2101, an anti-KIR antibody, in patients with relapsed/refractory MM. IPH2101 was administered intravenously every 28 days in ...[more]