Ontology highlight
ABSTRACT:
SUBMITTER: Poulsen EG
PROVIDER: S-EPMC3507821 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
PloS one 20121127 11
In eukaryotic cells an uncleavable ubiquitin moiety conjugated to the N-terminus of a protein signals the degradation of the fusion protein via the proteasome-dependent ubiquitin fusion degradation (UFD) pathway. In yeast the molecular mechanism of the UFD pathway has been well characterized. Recently the human E3 ubiquitin-protein ligase TRIP12 was connected with the UFD pathway, but little is otherwise known about this system in mammalian cells. In the present work, we utilized high-throughput ...[more]