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Proof of Concept: Matrix metalloproteinase inhibitor decreases inflammation and improves muscle insulin sensitivity in people with type 2 diabetes.

ABSTRACT: UNLABELLED: BACKGROUND:Obesity is a state of subclinical inflammation resulting in loss of function of insulin receptors and decreased insulin sensitivity. Inhibition of the inflammatory enzymes, matrix metalloproteinases (MMPs), for 6 months in rodent models restores insulin receptor function and insulin sensitivity. METHODS:This 12-week double-blind, randomized, placebo (PL)-controlled proof-of-concept study was performed to determine if the MMP inhibitor (MMPI), doxycycline, decreased global markers of inflammation and enhanced muscle insulin sensitivity in obese people with type 2 diabetes (DM2). The study included non-DM2 controls (n?=?15), and DM2 subjects randomized to PL (n?=?13) or doxycycline 100 mg twice daily (MMPI; n?=?11). All participants were evaluated on Day 1; MMPI and PL groups were also evaluated after 84 days of treatment. RESULTS:There was a significant decrease in inflammatory markers C-reactive protein (P?

SUBMITTER: Frankwich K 

PROVIDER: S-EPMC3507843 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature

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Proof of Concept: Matrix metalloproteinase inhibitor decreases inflammation and improves muscle insulin sensitivity in people with type 2 diabetes.

Frankwich Karen K   Tibble Courtney C   Torres-Gonzalez Moises M   Bonner Mariah M   Lefkowitz Roy R   Tyndall Matt M   Schmid-Schönbein Geert W GW   Villarreal Francisco F   Heller Mike M   Herbst Karen K  

Journal of inflammation (London, England) 20121001 1

<h4>Unlabelled</h4><h4>Background</h4>Obesity is a state of subclinical inflammation resulting in loss of function of insulin receptors and decreased insulin sensitivity. Inhibition of the inflammatory enzymes, matrix metalloproteinases (MMPs), for 6 months in rodent models restores insulin receptor function and insulin sensitivity.<h4>Methods</h4>This 12-week double-blind, randomized, placebo (PL)-controlled proof-of-concept study was performed to determine if the MMP inhibitor (MMPI), doxycycl  ...[more]

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