Ontology highlight
ABSTRACT:
SUBMITTER: D'Aiuto L
PROVIDER: S-EPMC3507916 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
D'Aiuto Leonardo L Di Maio Roberto R Heath Brianna B Raimondi Giorgio G Milosevic Jadranka J Watson Annie M AM Bamne Mikhil M Parks W Tony WT Yang Lei L Lin Bo B Miki Toshio T Mich-Basso Jocelyn Danielle JD Arav-Boger Ravit R Sibille Etienne E Sabunciyan Sarven S Yolken Robert R Nimgaonkar Vishwajit V
PloS one 20121127 11
Human cytomegalovirus (HCMV) infection is one of the leading prenatal causes of congenital mental retardation and deformities world-wide. Access to cultured human neuronal lineages, necessary to understand the species specific pathogenic effects of HCMV, has been limited by difficulties in sustaining primary human neuronal cultures. Human induced pluripotent stem (iPS) cells now provide an opportunity for such research. We derived iPS cells from human adult fibroblasts and induced neural lineage ...[more]