Ontology highlight
ABSTRACT:
SUBMITTER: Kaehler C
PROVIDER: S-EPMC3507954 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Kaehler Christian C Isensee Jörg J Nonhoff Ute U Terrey Markus M Hucho Tim T Lehrach Hans H Krobitsch Sylvia S
PloS one 20121127 11
Paralogs for several proteins implicated in neurodegenerative disorders have been identified and explored to further facilitate the identification of molecular mechanisms contributing to disease pathogenesis. For the disease-causing protein in spinocerebellar ataxia type 2, ataxin-2, a paralog of unknown function, termed ataxin-2-like, has been described. We discovered that ataxin-2-like associates with known interaction partners of ataxin-2, the RNA helicase DDX6 and the poly(A)-binding protein ...[more]