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ABSTRACT:
SUBMITTER: Katigbak J
PROVIDER: S-EPMC3507992 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Katigbak Joseph J Zhang Yong Y
The journal of physical chemistry letters 20121101 3
Fur protein plays key roles in regulating numerous genes in bacteria and is essential for intracellular iron concentration regulation. However, atomic level pictures of the iron binding site and its functional mechanism remain to be established. Here we present results of the first quantum chemical investigation of various first- and second-shell models and experimental Mössbauer data of E. Coli Fur, including 1) the first robust evidence that site 2 is the Fe binding site with a 3His/2Glu ligan ...[more]