P53, SKP2, and DKK3 as MYCN Target Genes and Their Potential Therapeutic Significance.
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ABSTRACT:
SUBMITTER: Chen L
PROVIDER: S-EPMC3508619 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
p53, SKP2, and DKK3 as MYCN Target Genes and Their Potential Therapeutic Significance.
Chen Lindi L Tweddle Deborah A DA
Frontiers in oncology 20121128
Neuroblastoma is the most common extra-cranial solid tumor of childhood. Despite significant advances, it currently still remains one of the most difficult childhood cancers to cure, with less than 40% of patients with high-risk disease being long-term survivors. MYCN is a proto-oncogene implicated to be directly involved in neuroblastoma development. Amplification of MYCN is associated with rapid tumor progression and poor prognosis. Novel therapeutic strategies which can improve the survival r ...[more]
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