Ontology highlight
ABSTRACT:
SUBMITTER: Jiang R
PROVIDER: S-EPMC3508781 | biostudies-literature | 2012 Sep-Oct
REPOSITORIES: biostudies-literature
Jiang Ruotian R Taly Antoine A Lemoine Damien D Martz Adeline A Specht Alexandre A Grutter Thomas T
Channels (Austin, Tex.) 20120901 5
The molecular mechanism underlying channel opening in response to agonist binding remains a challenging issue in neuroscience. In this regard, many efforts have been recently undertaken in ATP-gated P2X receptors. Among those efforts, we have provided evidence in the P2X2 receptor that tightening of ATP sites upon agonist binding induces opening of the ion channel. Here we extend our analysis to show that the sulfhydryl-reactive ATP analog 8-thiocyano-ATP (NCS-ATP), a potent P2X2 agonist, when c ...[more]