Dataset Information

5-HTTLPR and early childhood adversities moderate cognitive and emotional processing in adolescence.

ABSTRACT:

Background

Polymorphisms in the promoter region of the serotonin transporter gene (5-HTTLPR) and exposure to early childhood adversities (CA) are independently associated with individual differences in cognitive and emotional processing. Whether these two factors interact to influence cognitive and emotional processing is not known.

Methodology and principal findings

We used a sample of 238 adolescents from a community study characterised by the presence of the short allele of 5-HTTLPR (LL, LS, SS) and the presence or absence of exposure to CA before 6 years of age. We measured cognitive and emotional processing using a set of neuropsychological tasks selected predominantly from the CANTAB® battery. We found that adolescents homozygous for the short allele (SS) of 5-HTTLPR and exposed to CA were worse at classifying negative and neutral stimuli and made more errors in response to ambiguous negative feedback. In addition, cognitive and emotional processing deficits were associated with diagnoses of anxiety and/or depressions.

Conclusion and significance

Cognitive and emotional processing deficits may act as a transdiagnostic intermediate marker for anxiety and depressive disorders in genetically susceptible individuals exposed to CA.

SUBMITTER: Owens M

PROVIDER: S-EPMC3509124 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Publications

5-HTTLPR and early childhood adversities moderate cognitive and emotional processing in adolescence.

Owens Matthew M Goodyer Ian M IM Wilkinson Paul P Bhardwaj Anupam A Abbott Rosemary R Croudace Tim T Dunn Valerie V Jones Peter B PB Walsh Nicholas D ND Ban Maria M Sahakian Barbara J BJ

PloS one 20121128 11

<h4>Background</h4>Polymorphisms in the promoter region of the serotonin transporter gene (5-HTTLPR) and exposure to early childhood adversities (CA) are independently associated with individual differences in cognitive and emotional processing. Whether these two factors interact to influence cognitive and emotional processing is not known.<h4>Methodology and principal findings</h4>We used a sample of 238 adolescents from a community study characterised by the presence of the short allele of 5-H ...[more]

PMID: 23209555

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Dataset Information

5-HTTLPR and early childhood adversities moderate cognitive and emotional processing in adolescence.

Background

Methodology and principal findings

Conclusion and significance

Publications

5-HTTLPR and early childhood adversities moderate cognitive and emotional processing in adolescence.

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