Ontology highlight
ABSTRACT:
SUBMITTER: Morris VA
PROVIDER: S-EPMC3509939 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Morris Valerie A VA Punjabi Almira S AS Wells Robert C RC Wittkopp Cristina J CJ Vart Richard R Lagunoff Michael M
Virology 20120421 2
The predominant tumor cell of Kaposi's Sarcoma (KS) is the spindle cell, a cell of endothelial origin that expresses markers of lymphatic endothelium. In culture, Kaposi's Sarcoma-associated herpesvirus (KSHV) infection of blood endothelial cells drives expression of lymphatic endothelial cell specific markers, in a process that requires activation of the gp130 receptor and the JAK2/STAT3 and PI3K/AKT signaling pathways. While expression of each of the KSHV major latent genes in endothelial cell ...[more]