Interactions of Mn2+ with a non-self-complementary Z-type DNA duplex.

ABSTRACT: Crystal structures of the hexanucleotide d(CACGCG)·d(CGCGTG) were determined in two crystal lattices when different concentrations of the counterion Mn2+ were used in crystallization. The availability of Mn2+ during the crystallization process appears to play an important role in inducing different crystal packings that lead to crystals belonging to the two space groups P2(1) and P6(5). Analysis of the molecular interactions of Mn2+ with the Z-form duplexes shows direct coordination to the purine residues G and A.

SUBMITTER: Mandal PK 

PROVIDER: S-EPMC3509959 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature