Ontology highlight
ABSTRACT:
SUBMITTER: Monteleon CL
PROVIDER: S-EPMC3510012 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Monteleon Christine L CL Sedgwick Alanna A Hartsell Alyssa A Dai Michael M Whittington Catherine C Voytik-Harbin Sherry S D'Souza-Schorey Crislyn C
Molecular biology of the cell 20121010 23
Epithelial cysts comprise the structural units of the glandular epithelium. Although glandular inversion in epithelial tumors is thought to be a potential mechanism for the establishment of metastatic disease, little is known about the morphogenic cues and signaling pathways that govern glandular polarity and organization. Using organotypic cultures of Madin-Darby canine kidney cells in reconstituted basement membrane, we show that cellular depletion of the small GTP-binding protein ARF6 promote ...[more]