Ontology highlight
ABSTRACT:
SUBMITTER: Tan SX
PROVIDER: S-EPMC3510527 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Tan Shi-Xiong SX Ng Yvonne Y Burchfield James G JG Ramm Georg G Lambright David G DG Stöckli Jacqueline J James David E DE
Molecular and cellular biology 20121008 24
The Rab GTPase-activating protein TBC1D4/AS160 regulates GLUT4 trafficking in adipocytes. Nonphosphorylated AS160 binds to GLUT4 vesicles and inhibits GLUT4 translocation, and AS160 phosphorylation overcomes this inhibitory effect. In the present study we detected several new functional features of AS160. The second phosphotyrosine-binding domain in AS160 encodes a phospholipid-binding domain that facilitates plasma membrane (PM) targeting of AS160, and this function is conserved in other relate ...[more]