Ontology highlight
ABSTRACT:
SUBMITTER: Chu HH
PROVIDER: S-EPMC3510669 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Chu H Hamlet HH Moon James J JJ Kruse Andrew C AC Pepper Marion M Jenkins Marc K MK
Journal of immunology (Baltimore, Md. : 1950) 20100922 8
Naive CD4(+) T cell populations that express TCRs specific for different foreign peptide-MHC class II complex (pMHCII) ligands can vary in size over several orders of magnitude. This variation may explain why immune responses to some peptides are stronger than others. In this study, we used a sensitive pMHCII-tetramer-based cell enrichment method to study the derivation of two naive foreign pMHCII-specific naive CD4(+) T cell populations that differed in size by 8-fold in normal mice. Analysis o ...[more]