Automated synthesis of sialylated oligosaccharides.

ABSTRACT: Sialic acid-containing glycans play a major role in cell-surface interactions with external partners such as cells and viruses. Straightforward access to sialosides is required in order to study their biological functions on a molecular level. Here, automated oligosaccharide synthesis was used to facilitate the preparation of this class of biomolecules. Our strategy relies on novel sialyl α-(2→3) and α-(2→6) galactosyl imidates, which, used in combination with the automated platform, provided rapid access to a small library of conjugation-ready sialosides of biological relevance.

SUBMITTER: Esposito D 

PROVIDER: S-EPMC3510992 | biostudies-literature |

REPOSITORIES: biostudies-literature