Ontology highlight
ABSTRACT:
SUBMITTER: Guardiola O
PROVIDER: S-EPMC3511144 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Guardiola Ombretta O Lafuste Peggy P Brunelli Silvia S Iaconis Salvatore S Touvier Thierry T Mourikis Philippos P De Bock Katrien K Lonardo Enza E Andolfi Gennaro G Bouché Ann A Liguori Giovanna L GL Shen Michael M MM Tajbakhsh Shahragim S Cossu Giulio G Carmeliet Peter P Minchiotti Gabriella G
Proceedings of the National Academy of Sciences of the United States of America 20121105 47
Skeletal muscle regeneration mainly depends on satellite cells, a population of resident muscle stem cells. However, our understanding of the molecular mechanisms underlying satellite cell activation is still largely undefined. Here, we show that Cripto, a regulator of early embryogenesis, is a novel regulator of muscle regeneration and satellite cell progression toward the myogenic lineage. Conditional inactivation of cripto in adult satellite cells compromises skeletal muscle regeneration, whe ...[more]