Ontology highlight
ABSTRACT:
SUBMITTER: Ross D
PROVIDER: S-EPMC3511313 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Ross Daniela D Saxena Manisha M Altmann Michael M
PloS one 20121130 11
eIF4E, the cytoplasmatic cap-binding protein, is required for efficient cap-dependent translation. We have studied the influence of mutations that alter the activity and/or expression level of eIF4E on haploid and diploid cells in the yeast S. cerevisiae. Temperature-sensitive eIF4E mutants with reduced levels of expression and reduced cap-binding affinity clearly show a loss in haploid adhesion and diploid pseudohyphenation upon starvation for nitrogen. Some of these mutations affect the intera ...[more]