Ontology highlight
ABSTRACT:
SUBMITTER: Takaesu G
PROVIDER: S-EPMC3511369 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Takaesu Giichi G Inagaki Maiko M Takubo Keiyo K Mishina Yuji Y Hess Paul R PR Dean Gregg A GA Yoshimura Akihiko A Matsumoto Kunihiro K Suda Toshio T Ninomiya-Tsuji Jun J
PloS one 20121130 11
A cytokine/stress signaling kinase Tak1 (Map3k7) deficiency is known to impair hematopoietic progenitor cells. However, the role of TAK1 signaling in the stem cell function of the hematopoietic system is not yet well defined. Here we characterized hematopoietic stem cells (HSCs) harboring deletion of Tak1 and its activators, Tak1 binding proteins 1 and 2 (Tab1 and Tab2) using a competitive transplantation assay in a mouse model. Tak1 single or Tab1/Tab2 double deletions completely eliminated the ...[more]