Ontology highlight
ABSTRACT:
SUBMITTER: Wagener J
PROVIDER: S-EPMC3511564 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Wagener Jeanette J Weindl Günther G de Groot Piet W J PW de Boer Albert D AD Kaesler Susanne S Thavaraj Selvam S Bader Oliver O Mailänder-Sanchez Daniela D Borelli Claudia C Weig Michael M Biedermann Tilo T Naglik Julian R JR Korting Hans Christian HC Schaller Martin M
PloS one 20121130 11
C. albicans is one of the most common fungal pathogen of humans, causing local and superficial mucosal infections in immunocompromised individuals. Given that the key structure mediating host-C. albicans interactions is the fungal cell wall, we aimed to identify features of the cell wall inducing epithelial responses and be associated with fungal pathogenesis. We demonstrate here the importance of cell wall protein glycosylation in epithelial immune activation with a predominant role for the hig ...[more]