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Mortality and causes of death in the Familial Intracranial Aneurysm study.

ABSTRACT: Higher mortality for patients with aneurysmal subarachnoid haemorrhage has been reported.In families with intracranial aneurysms, we sought to determine whether mortality among subjects with intracranial aneurysm (affected) was higher and related to rupture, compared with unaffected family members.Subjects enrolled in the Familial Intracranial Aneurysm protocol were contacted yearly and their status was obtained. If reported to be deceased, the cause of death was verified by available records. A Cox proportional hazards model was utilized to compare mortality rates.Of the 2794 subjects, 1073 were affected and 1721 were unaffected. There were 8525 person-years of follow-up (mean 3·05?±?1·73 years) and 85 deaths. Age at study entry for the affected (58·4?±?11·9 years) was significantly older (P?

SUBMITTER: Sauerbeck L

PROVIDER: S-EPMC3511628 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature

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Mortality and causes of death in the Familial Intracranial Aneurysm study.

Sauerbeck Laura L Hornung Richard R Woo Daniel D Moomaw Charles J CJ Anderson Craig C Connolly E Sander ES Rouleau Guy A GA Brown Robert D RD Broderick Joseph P JP

International journal of stroke : official journal of the International Stroke Society 20120829 8

<h4>Background</h4>Higher mortality for patients with aneurysmal subarachnoid haemorrhage has been reported.<h4>Aims</h4>In families with intracranial aneurysms, we sought to determine whether mortality among subjects with intracranial aneurysm (affected) was higher and related to rupture, compared with unaffected family members.<h4>Methods</h4>Subjects enrolled in the Familial Intracranial Aneurysm protocol were contacted yearly and their status was obtained. If reported to be deceased, the cau ...[more]

PMID: 22928607

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Project description:<p>Our long-term objective is to identify susceptibility genes that are related to the formation of intracranial aneurysms (IA). Rupture of IAs occurs in 16,000 to 17,000 persons in the U.S. annually and nearly half of affected persons are dead within the first 30 days. An additional 6,000 to 7,000 persons with unruptured IAs are identified each year. Accumulated evidence indicates that a genetic component plays an important role in the development of IAs, but specific loci affecting the risk of IA have not been identified. The primary hypothesis of this study is that there are specific human chromosomal regions that are associated with an increased risk of IAs. Specific Aims of are: <ol> <li>Recruitment of 400 (475) families with multiple individuals who have an IA through 23 (25) referral centers throughout North America, Australia, and New Zealand that represent 35 (40) recruitment sites.</li> <li>Ascertainment of interviews and blood samples from all affected family members as well as their first-degree relatives. White blood cells from living persons with an IA will be cryopreserved at Coriell Institute for Medical Research for future immortalization of cells lines as indicated.</li> <li>Identification of unruptured IAs by obtaining MRAs in selected asymptomatic siblings (of affected individuals).</li> <li>Completion of a 10 cM genome series in persons with IAs as well as the spouses and children of persons with an IA who are deceased. We will perform finer mapping of chromosomal regions with suggestive evidence of linkage in the genome screen.</li> <li>Performance of a nonparametric (allele sharing) linkage analysis, including relevant environmental factors such as smoking, to identify chromosomal regions linked to IA. Reconstruction of the genotypes of deceased affected family members will be performed.</li> </ol> </p> <p>Identification of individuals who are genetically at high risk for the development of IAs would enable targeted and effective screening/prevention/treatment strategies to reduce the substantial mortality and morbidity associated with this devastating type of stroke. Only a multidisciplinary, collaborative effort to identify, accrue, and genotype FIA families will be successful in identifying sufficient high-risk families to characterize the genetic underpinnings of IA.</p>

Dataset Information

Mortality and causes of death in the Familial Intracranial Aneurysm study.

Publications

Mortality and causes of death in the Familial Intracranial Aneurysm study.

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