Ontology highlight
ABSTRACT:
SUBMITTER: Tibayrenc M
PROVIDER: S-EPMC3511763 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Tibayrenc Michel M Ayala Francisco J FJ
Proceedings of the National Academy of Sciences of the United States of America 20120904 48
We propose that clonal evolution in micropathogens be defined as restrained recombination on an evolutionary scale, with genetic exchange scarce enough to not break the prevalent pattern of clonal population structure, a definition already widely used for all kinds of pathogens, although not clearly formulated by many scientists and rejected by others. The two main manifestations of clonal evolution are strong linkage disequilibrium (LD) and widespread genetic clustering ("near-clading"). We hyp ...[more]