Ontology highlight
ABSTRACT:
SUBMITTER: Miao Y
PROVIDER: S-EPMC3512040 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Miao Yinglong Y Yi Zheng Z Cantrell Carey C Glass Dennis C DC Baudry Jerome J Jain Nitin N Smith Jeremy C JC
Biophysical journal 20121120 10
Neutron scattering and nuclear magnetic resonance relaxation experiments are combined with molecular dynamics (MD) simulations in a novel, to our knowledge, approach to investigate the change in internal dynamics on substrate (camphor) binding to a protein (cytochrome P450cam). The MD simulations agree well with both the neutron scattering, which furnishes information on global flexibility, and the nuclear magnetic resonance data, which provides residue-specific order parameters. Decreased fluct ...[more]