A decision rule for quantitative trait locus detection under the extended Bayesian LASSO model.
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ABSTRACT:
SUBMITTER: Mutshinda CM
PROVIDER: S-EPMC3512153 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
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A decision rule for quantitative trait locus detection under the extended Bayesian LASSO model.
Mutshinda Crispin M CM Sillanpää Mikko J MJ
Genetics 20120914 4
Bayesian shrinkage analysis is arguably the state-of-the-art technique for large-scale multiple quantitative trait locus (QTL) mapping. However, when the shrinkage model does not involve indicator variables for marker inclusion, QTL detection remains heavily dependent on significance thresholds derived from phenotype permutation under the null hypothesis of no phenotype-to-genotype association. This approach is computationally intensive and more importantly, the hypothetical data generation at t ...[more]
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2018-01-25 | E-MTAB-5572 | biostudies-arrayexpress