Ontology highlight
ABSTRACT:
SUBMITTER: Papantonis A
PROVIDER: S-EPMC3512387 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Papantonis Argyris A Kohro Takahide T Baboo Sabyasachi S Larkin Joshua D JD Deng Binwei B Short Patrick P Tsutsumi Shuichi S Taylor Stephen S Kanki Yasuharu Y Kobayashi Mika M Li Guoliang G Poh Huay-Mei HM Ruan Xiaoan X Aburatani Hiroyuki H Ruan Yijun Y Kodama Tatsuhiko T Wada Youichiro Y Cook Peter R PR
The EMBO journal 20121026 23
Tumour necrosis factor alpha (TNFα) is a potent cytokine that signals through nuclear factor kappa B (NFκB) to activate a subset of human genes. It is usually assumed that this involves RNA polymerases transcribing responsive genes wherever they might be in the nucleus. Using primary human endothelial cells, variants of chromosome conformation capture (including 4C and chromatin interaction analysis with paired-end tag sequencing), and fluorescence in situ hybridization to detect single nascent ...[more]