Unknown

Dataset Information

0

Functional divergence of gene duplicates through ectopic recombination.


ABSTRACT: Gene duplication stimulates evolutionary innovation as the resulting paralogs acquire mutations that lead to sub- or neofunctionalization. A comprehensive in silico analysis of paralogs in Saccharomyces cerevisiae reveals that duplicates of cell-surface and subtelomeric genes also undergo ectopic recombination, which leads to new chimaeric alleles. Mimicking such intergenic recombination events in the FLO (flocculation) family of cell-surface genes shows that chimaeric FLO alleles confer different adhesion phenotypes than the parental genes. Our results indicate that intergenic recombination between paralogs can generate a large set of new alleles, thereby providing the raw material for evolutionary adaptation and innovation.

SUBMITTER: Christiaens JF 

PROVIDER: S-EPMC3512402 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications


Gene duplication stimulates evolutionary innovation as the resulting paralogs acquire mutations that lead to sub- or neofunctionalization. A comprehensive in silico analysis of paralogs in Saccharomyces cerevisiae reveals that duplicates of cell-surface and subtelomeric genes also undergo ectopic recombination, which leads to new chimaeric alleles. Mimicking such intergenic recombination events in the FLO (flocculation) family of cell-surface genes shows that chimaeric FLO alleles confer differe  ...[more]

Similar Datasets

| S-EPMC3426493 | biostudies-literature
| S-EPMC3971588 | biostudies-literature
| S-EPMC8042753 | biostudies-literature
| S-EPMC3936732 | biostudies-literature
| S-EPMC7084467 | biostudies-literature
| S-EPMC5715747 | biostudies-literature
| S-EPMC3190396 | biostudies-literature
| S-EPMC7603692 | biostudies-literature
| S-EPMC4256066 | biostudies-literature
| S-EPMC3014980 | biostudies-literature