Functional divergence of gene duplicates through ectopic recombination.
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ABSTRACT:
SUBMITTER: Christiaens JF
PROVIDER: S-EPMC3512402 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Publications
Functional divergence of gene duplicates through ectopic recombination.
Christiaens Joaquin F JF Van Mulders Sebastiaan E SE Duitama Jorge J Brown Chris A CA Ghequire Maarten G MG De Meester Luc L Michiels Jan J Wenseleers Tom T Voordeckers Karin K Verstrepen Kevin J KJ
EMBO reports 20121016 12
Gene duplication stimulates evolutionary innovation as the resulting paralogs acquire mutations that lead to sub- or neofunctionalization. A comprehensive in silico analysis of paralogs in Saccharomyces cerevisiae reveals that duplicates of cell-surface and subtelomeric genes also undergo ectopic recombination, which leads to new chimaeric alleles. Mimicking such intergenic recombination events in the FLO (flocculation) family of cell-surface genes shows that chimaeric FLO alleles confer differe ...[more]
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