Reactive oxygen species regulate ERBB2 and ERBB3 expression via miR-199a/125b and DNA methylation.
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ABSTRACT:
SUBMITTER: He J
PROVIDER: S-EPMC3512405 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Publications
Reactive oxygen species regulate ERBB2 and ERBB3 expression via miR-199a/125b and DNA methylation.
He Jun J Xu Qing Q Jing Yi Y Agani Faton F Qian Xu X Carpenter Richard R Li Qi Q Wang Xin-Ru XR Peiper Stephen S SS Lu Zhimin Z Liu Ling-Zhi LZ Jiang Bing-Hua BH
EMBO reports 20121113 12
Overexpression of ERBB2 or ERBB3 is associated with cancer development and poor prognosis. In this study, we show that reactive oxygen species (ROS) induce both ERBB2 and ERBB3 expression in vitro and in vivo. We also identify that miR-199a and miR-125b target ERBB2 and/or ERBB3 in ovarian cancer cells, and demonstrate that ROS inhibit miR-199a and miR-125b expression through increasing the promoter methylation of the miR-199a and miR-125b genes by DNA methyltransferase 1. These findings reveal ...[more]
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