Ontology highlight
ABSTRACT:
SUBMITTER: Subudhi SK
PROVIDER: S-EPMC351315 | biostudies-literature | 2004 Mar
REPOSITORIES: biostudies-literature
Subudhi Sumit K SK Zhou Ping P Yerian Lisa M LM Chin Robert K RK Lo James C JC Anders Robert A RA Sun Yonglian Y Chen Lieping L Wang Yang Y Alegre Maria-Luisa ML Fu Yang-Xin YX
The Journal of clinical investigation 20040301 5
A number of studies have suggested B7-H1, a B7 family member, inhibits T cell responses. Therefore, its expression on nonlymphoid tissues has been proposed to prevent T cell-mediated tissue destruction. To test this hypothesis, we generated transgenic mice that expressed B7-H1 on pancreatic islet beta cells. Surprisingly, we observed accelerated rejection of transplanted allogeneic B7-H1-expressing islet beta cells. Furthermore, transgenic B7-H1 expression broke immune tolerance, as some of the ...[more]