Ontology highlight
ABSTRACT:
SUBMITTER: Xu H
PROVIDER: S-EPMC3513378 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Xu Haixia H Zhu Jimmy J Smith Sinead S Foldi Julia J Zhao Baohong B Chung Allen Y AY Outtz Hasina H Kitajewski Jan J Shi Chao C Weber Silvio S Saftig Paul P Li Yueming Y Ozato Keiko K Blobel Carl P CP Ivashkiv Lionel B LB Hu Xiaoyu X
Nature immunology 20120520 7
Emerging concepts suggest that the functional phenotype of macrophages is regulated by transcription factors that define alternative activation states. We found that RBP-J, the main nuclear transducer of signaling via Notch receptors, augmented Toll-like receptor 4 (TLR4)-induced expression of key mediators of classically activated M1 macrophages and thus of innate immune responses to Listeria monocytogenes. Notch-RBP-J signaling controlled expression of the transcription factor IRF8 that induce ...[more]