Ontology highlight
ABSTRACT:
SUBMITTER: Orozco LD
PROVIDER: S-EPMC3513387 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Orozco Luz D LD Bennett Brian J BJ Farber Charles R CR Ghazalpour Anatole A Pan Calvin C Che Nam N Wen Pingzi P Qi Hong Xiu HX Mutukulu Adonisa A Siemers Nathan N Neuhaus Isaac I Yordanova Roumyana R Gargalovic Peter P Pellegrini Matteo M Kirchgessner Todd T Lusis Aldons J AJ
Cell 20121001 3
Many common diseases have an important inflammatory component mediated in part by macrophages. Here we used a systems genetics strategy to examine the role of common genetic variation in macrophage responses to inflammatory stimuli. We examined genome-wide transcript levels in macrophages from 92 strains of the Hybrid Mouse Diversity Panel. We exposed macrophages to control media, bacterial lipopolysaccharide (LPS), or oxidized phospholipids. We performed association mapping under each condition ...[more]