Ontology highlight
ABSTRACT:
SUBMITTER: Jacobson PA
PROVIDER: S-EPMC3513646 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Jacobson P A PA Schladt D D Oetting W S WS Leduc R R Guan W W Matas A J AJ Israni A A
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20120904 12
The number of older adults undergoing kidney transplantation has increased, yet little is known about calcineurin inhibitor (CNI) metabolism in this group. We studied CNI troughs and doses to determine if there were age-related differences in metabolism and dose requirements. We studied 348 young (18-34 years), 1831 middle (35-64 years) and 374 older (65-84 years) adult kidney transplant recipients enrolled in a seven-center prospective study. Troughs were obtained from each patient 2×/week in w ...[more]