Ontology highlight
ABSTRACT:
SUBMITTER: Feltrin D
PROVIDER: S-EPMC3514283 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Feltrin Daniel D Fusco Ludovico L Witte Harald H Moretti Francesca F Martin Katrin K Letzelter Michel M Fluri Erika E Scheiffele Peter P Pertz Olivier O
PLoS biology 20121204 12
Local mRNA translation in neurons has been mostly studied during axon guidance and synapse formation but not during initial neurite outgrowth. We performed a genome-wide screen for neurite-enriched mRNAs and identified an mRNA that encodes mitogen-activated protein kinase kinase 7 (MKK7), a MAP kinase kinase (MAPKK) for Jun kinase (JNK). We show that MKK7 mRNA localizes to the growth cone where it has the potential to be translated. MKK7 is then specifically phosphorylated in the neurite shaft, ...[more]