Ontology highlight
ABSTRACT:
SUBMITTER: Oliva AA
PROVIDER: S-EPMC3514616 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Oliva Anthony A AA Kang Yuan Y Furones Concepcion C Alonso Ofelia F OF Bruno Olga O Dietrich W Dalton WD Atkins Coleen M CM
Journal of neurochemistry 20121101 6
Traumatic brain injury (TBI) results in significant inflammation which contributes to the evolving pathology. Previously, we have demonstrated that cyclic AMP (cAMP), a molecule involved in inflammation, is down-regulated after TBI. To determine the mechanism by which cAMP is down-regulated after TBI, we determined whether TBI induces changes in phosphodiesterase (PDE) expression. Adult male Sprague Dawley rats received moderate parasagittal fluid-percussion brain injury (FPI) or sham injury, an ...[more]