Neuromedins U and S involvement in the regulation of the hypothalamo-pituitary-adrenal axis.
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ABSTRACT:
SUBMITTER: Malendowicz LK
PROVIDER: S-EPMC3514618 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
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Neuromedins U and S involvement in the regulation of the hypothalamo-pituitary-adrenal axis.
Malendowicz Ludwik K LK Ziolkowska Agnieszka A Rucinski Marcin M
Frontiers in endocrinology 20121205
We reviewed neuromedin U (NMU) and neuromedin S (NMS) involvement in the regulation of the hypothalamo-pituitary-adrenal (HPA) axis function. NMU and NMS are structurally related and highly conserved neuropeptides. They exert biological effects via two GPCR receptors designated as NMUR1 and NMUR2 which show differential expression. NMUR1 is expressed predominantly at the periphery, while NMUR2 in the central nervous system. Elements of the NMU/NMS and their receptors network are also expressed i ...[more]
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