Sex-biased genetic effects on gene regulation in humans.
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ABSTRACT:
SUBMITTER: Dimas AS
PROVIDER: S-EPMC3514666 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Publications
Sex-biased genetic effects on gene regulation in humans.
Dimas Antigone S AS Nica Alexandra C AC Montgomery Stephen B SB Stranger Barbara E BE Raj Towfique T Buil Alfonso A Giger Thomas T Lappalainen Tuuli T Gutierrez-Arcelus Maria M McCarthy Mark I MI Dermitzakis Emmanouil T ET
Genome research 20120907 12
Human regulatory variation, reported as expression quantitative trait loci (eQTLs), contributes to differences between populations and tissues. The contribution of eQTLs to differences between sexes, however, has not been investigated to date. Here we explore regulatory variation in females and males and demonstrate that 12%-15% of autosomal eQTLs function in a sex-biased manner. We show that genes possessing sex-biased eQTLs are expressed at similar levels across the sexes and highlight cases o ...[more]
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