Ontology highlight
ABSTRACT:
SUBMITTER: Lee SM
PROVIDER: S-EPMC3514783 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
The Journal of cell biology 20121119 5
Mutations in small integral membrane protein of lysosome/late endosome (SIMPLE) cause autosomal dominant, Charcot-Marie-Tooth disease (CMT) type 1C. The cellular function of SIMPLE is unknown and the pathogenic mechanism of SIMPLE mutations remains elusive. Here, we report that SIMPLE interacted and colocalized with endosomal sorting complex required for transport (ESCRT) components STAM1, Hrs, and TSG101 on early endosomes and functioned with the ESCRT machinery in the control of endosome-to-ly ...[more]