Dataset Information

Genome sequences of wild and domestic bactrian camels.

ABSTRACT: Bactrian camels serve as an important means of transportation in the cold desert regions of China and Mongolia. Here we present a 2.01?Gb draft genome sequence from both a wild and a domestic bactrian camel. We estimate the camel genome to be 2.38?Gb, containing 20,821 protein-coding genes. Our phylogenomics analysis reveals that camels shared common ancestors with other even-toed ungulates about 55-60 million years ago. Rapidly evolving genes in the camel lineage are significantly enriched in metabolic pathways, and these changes may underlie the insulin resistance typically observed in these animals. We estimate the genome-wide heterozygosity rates in both wild and domestic camels to be 1.0 × 10(-3). However, genomic regions with significantly lower heterozygosity are found in the domestic camel, and olfactory receptors are enriched in these regions. Our comparative genomics analyses may also shed light on the genetic basis of the camel's remarkable salt tolerance and unusual immune system.

SUBMITTER: Bactrian Camels Genome Sequencing and Analysis Consortium

PROVIDER: S-EPMC3514880 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Genome sequences of wild and domestic bactrian camels.

Jirimutu Wang Zhen Z Ding Guohui G Chen Gangliang G Sun Yamin Y Sun Zhihong Z Zhang Heping H Wang Lei L Hasi Surong S Zhang Yan Y Li Jianmei J Shi Yixiang Y Xu Ze Z He Chuan C Yu Siriguleng S Li Shengdi S Zhang Wenbin W Batmunkh Mijiddorj M Ts Batsukh B Narenbatu Unierhu Bat-Ireedui Shirzana S Gao Hongwei H Baysgalan Banzragch B Li Qing Q Jia Zhiling Z Turigenbayila Subudenggerile Narenmanduhu Wang Zhaoxia Z Wang Juan J Pan Lei L Chen Yongcan Y Ganerdene Yaichil Y Dabxilt Erdemt Altansha Altansukh Liu Tuya T Cao Minhui M Aruuntsever Bayart Hosblig He Fei F Zha-ti A A Zheng Guangyong G Qiu Feng F Sun Zikui Z Zhao Lele L Zhao Wenjing W Liu Baohong B Li Chao C Chen Yunqin Y Tang Xiaoyan X Guo Chunyan C Liu Wei W Ming Liang L Temuulen Cui Aiying A Li Yi Y Gao Junhui J Li Jing J Wurentaodi Niu Shen S Sun Tao T Zhai Zhengxiao Z Zhang Min M Chen Chen C Baldan Tunteg T Bayaer Tuman T Li Yixue Y Meng He H

Nature communications 20120101

Bactrian camels serve as an important means of transportation in the cold desert regions of China and Mongolia. Here we present a 2.01 Gb draft genome sequence from both a wild and a domestic bactrian camel. We estimate the camel genome to be 2.38 Gb, containing 20,821 protein-coding genes. Our phylogenomics analysis reveals that camels shared common ancestors with other even-toed ungulates about 55-60 million years ago. Rapidly evolving genes in the camel lineage are significantly enriched in m ...[more]

PMID: 23149746

Similar Datasets

Project description:BACKGROUND:More information on brucellosis epidemiology in Bactrian camels is needed due to their growing economic and livelihood importance for herders and renewed efforts in Mongolia to eliminate brucellosis through mass vaccination of ruminants excluding camels. Brucellosis prevalence in camels increased over the past two decades. Random multi-stage cluster surveys were done in the Eastern provinces of Dornod and Sukhbaatar in 2013 and 2014 and in the Southern & Western provinces of Dornogobi, Umnogobi and Khovd in 2014 and 2015. A total of 1822 camels, 1155 cattle, and 3023 small ruminant sera were collected and tested with the Rose Bengal Test. In addition, 195 vaginal swabs and 250 milk samples for bacteriological culture were taken from livestock with history of abortion. RESULTS:The overall apparent seroprevalence in camels was 2.3% (95% confidence interval 1.6-3.3). The main risk factor for camel seropositivity was being in an Eastern province when compared to Southern & Western provinces (odds ratio 13.2, 95% CI 5.3-32.4). Camel seroprevalences were stable over the two consecutive survey years, despite introduction of ruminant vaccination: 5.7% (95% CI 3.1-10.2%) and 5.8% (3.3-10.1%) in Eastern provinces and 0.4% (0.2-1.2%) and 0.5% (0.1-2.0%) in Southern & Western provinces. We isolated Brucella abortus from camels and cattle. Camel seropositivity was associated to keeping cattle together with camels. Monitoring of vaccination campaigns showed that coverage in cattle was insufficient because animals could not be adequately restrained. CONCLUSIONS:The present study reveals that brucellosis is present with important seroprevalence in Mongolian camels and was endemic in Eastern provinces. Camel herd seropositivity was most closely associated to infection in cattle. Longer term monitoring is needed to assess whether camel seroprevalance decreases with ongoing vaccination in Mongolia. This should be coupled with further confirmation on Brucella spp. isolates. To date, only Brucella abortus was isolated, but camels are also susceptible to Brucella melitensis. Clear verbal and written information on disease prevention in livestock and household members is important, particularly for remote camel herders who had only moderate knowledge on brucellosis epidemiology and preventive measures.

Dataset Information

Genome sequences of wild and domestic bactrian camels.

Publications

Genome sequences of wild and domestic bactrian camels.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets