Ontology highlight
ABSTRACT:
SUBMITTER: Kastenmuller W
PROVIDER: S-EPMC3514884 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Kastenmüller Wolfgang W Torabi-Parizi Parizad P Subramanian Naeha N Lämmermann Tim T Germain Ronald N RN
Cell 20120901 6
The lymphatic network that transports interstitial fluid and antigens to lymph nodes constitutes a conduit system that can be hijacked by invading pathogens to achieve systemic spread unless dissemination is blocked in the lymph node itself. Here, we show that a network of diverse lymphoid cells (natural killer cells, γδ T cells, natural killer T cells, and innate-like CD8+ T cells) are spatially prepositioned close to lymphatic sinus-lining sentinel macrophages where they can rapidly and effici ...[more]