Ontology highlight
ABSTRACT:
SUBMITTER: Turke AB
PROVIDER: S-EPMC3515079 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Turke Alexa B AB Song Youngchul Y Costa Carlotta C Cook Rebecca R Arteaga Carlos L CL Asara John M JM Engelman Jeffrey A JA
Cancer research 20120502 13
The phosphoinositide 3-kinase (PI3K)/AKT and RAF/MEK/ERK signaling pathways are activated in a wide range of human cancers. In many cases, concomitant inhibition of both pathways is necessary to block proliferation and induce cell death and tumor shrinkage. Several feedback systems have been described in which inhibition of one intracellular pathway leads to activation of a parallel signaling pathway, thereby decreasing the effectiveness of single-agent targeted therapies. In this study, we desc ...[more]