Ontology highlight
ABSTRACT:
SUBMITTER: Ploemen IH
PROVIDER: S-EPMC3515443 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Ploemen Ivo H J IH Croes Huib J HJ van Gemert Geert-Jan J GJ Wijers-Rouw Mietske M Hermsen Cornelus C CC Sauerwein Robert W RW
PloS one 20121205 12
The proteins P52 and P36 are expressed in the sporozoite stage of the murine malaria parasite Plasmodium berghei. Δp52&p36 sporozoites lacking expression of both proteins are severely compromised in their capability to develop into liver stage parasites and abort development soon after invasion; presumably due to the absence of a parasitophorous vacuole membrane (PVM). However, a small proportion of P. berghei Δp52&p36 parasites is capable to fully mature in hepatocytes causing breakthrough bloo ...[more]