Perimetric and retinal nerve fiber layer findings in patients with Parkinson's disease.
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ABSTRACT:
SUBMITTER: Tsironi EE
PROVIDER: S-EPMC3515471 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Perimetric and retinal nerve fiber layer findings in patients with Parkinson's disease.
Tsironi Evangelia E EE Dastiridou Anna A Katsanos Andreas A Dardiotis Efthymios E Veliki Stella S Patramani Gianna G Zacharaki Fani F Ralli Stella S Hadjigeorgiou Georgios M GM
BMC ophthalmology 20121002
<h4>Background</h4>Visual dysfunction is common in Parkinson's disease (PD). It remains, however, unknown whether it is related to structural alterations of the retina. The aim of this study is to compare visual field (VF) findings and circumpapillary retinal nerve fiber layer (RNFL) thickness in a series of PD patients and normal controls, in order to assess possible retinal anatomical changes and/or functional damage associated with PD.<h4>Methods</h4>PD patients and controls were recruited an ...[more]
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Project description:The nerve fiber layer of the human retina is made up of the retinal segments of ganglion cell axons. Its geometry can be described mathematically as a fibration of a 2D domain: a partition of a certain region into smooth curves. Here, we present a simple family of curves that closely models the observed geometry of the nerve fiber layer. For each retina, the pattern depends on 2 parameters, A and B: A computer program determines A and B for a given retina and the theory matches the retina with a standard deviation of approximately 6-8 degrees . These particular curves turn out to be the curves that would be generated if the growing ganglion cell axon tip moved down a gradient toward a source of diffusible neuroattractant at the disk and away from a weaker macular diffusible repellant. Thus, this model provides morphological evidence that diffusible substances provide positional information to the embryonic ganglion cell axons in finding their way to the optic nerve head.
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Project description:Parkinson disease (PD) is a neurodegenerative process that leads to a selective loss of dopaminergic neurons, mainly in the basal ganglia of the brain. Numerous studies have analyzed the ability of optical coherence tomography (OCT) to detect retinal nerve fiber layer (RNFL) thickness abnormalities and changes in PD, but the results have not always been consistent. Therefore, we carried out a meta-analysis to evaluate the RNFL thickness measured with OCT in PD.Case-control studies were selected through an electronic search of the Cochrane Controlled Trials Register, PUBMED and EMBASE. For the continuous outcomes, we calculated the weighted mean difference (WMD) and 95% confidence interval (CI). The statistical analysis was performed by RevMan 5.0 software. Thirteen case-control studies were included in the present meta-analysis, containing a total of 644 eyes in PD patients and 604 eyes in healthy controls. The results of our study showed that there was a significant reduction in average RNFL thickness in patients with PD compared to healthy controls (WMD?=?-5.76, 95% CI: -8.99 to -2.53, P?=?0.0005). Additionally, differences of RNFL thickness in superior quadrant (WMD?=?-4.44, 95% CI: -6.93 to -1.94, P?=?0.0005), inferior quadrant (WMD?=?-7.56, 95% CI: -11.33 to -3.78, P<0.0001), nasal quadrant (WMD?=?-3.12, 95% CI: -5.63 to -0.61, P?=?0.01) and temporal quadrant (WMD?=?-4.63, 95% CI: -7.20 to -2.06, P?=?0.0004) were all significant between the two groups.In view of these results and the noninvasive nature of OCT technology, we surmise that OCT could be a useful tool for evaluating the progression of the Parkinson disease.ClinicalTrials.gov NCT01928212.
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