Ontology highlight
ABSTRACT:
SUBMITTER: Angeletti D
PROVIDER: S-EPMC3515580 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Angeletti Davide D Albrecht Letusa L Blomqvist Karin K Quintana María Del Pilar Mdel P Akhter Tahmina T Bächle Susanna M SM Sawyer Alan A Sandalova Tatyana T Achour Adnane A Wahlgren Mats M Moll Kirsten K
PloS one 20121205 12
The ability of Plasmodium falciparum parasitized RBC (pRBC) to form rosettes with normal RBC is linked to the virulence of the parasite and RBC polymorphisms that weaken rosetting confer protection against severe malaria. The adhesin PfEMP1 mediates the binding and specific antibodies prevent sequestration in the micro-vasculature, as seen in animal models. Here we demonstrate that epitopes targeted by rosette disrupting antibodies converge in the loop of subdomain 3 (SD3) which connects the h6 ...[more]